They work by decreasing acid production in the stomach for up to 12 hours. Examples include Famotidine (Zantac 360, Pepcid AC), Cimetidine (Tagamet HB), and Nizatidine (Axid, Azid AR).
They work by blocking acid production and healing the esophagus. Examples include omeprazole (Prilosec), esomeprazole (Nexium), and pantoprazole (Protonix).